The proton leak via uncoupling proteins makes mitochondria respiration more inefficient, thus generates more heat as by product. ... Instead, it causes higher level of mitochondrial respiration (more combustion) which generates heat.

What does an uncoupling protein do?

Uncoupling proteins are mitochondrial carrier proteins which are able to dissipate the proton gradient of the inner mitochondrial membrane. This uncoupling process reduces the amount of ATP generated through an oxidation of fuels.

How do uncoupling proteins help with thermoregulation?

UCP1, found in the mitochondrial inner membrane in BAT, uncouples energy substrate oxidation from mitochondrial ATP production and hence results in the loss of potential energy as heat. ... The hypothesis that the novel UCPs may regulate thermogenesis and/or fatty acid metabolism guides investigations worldwide.