Thus, acetylation of histones is known to increase the expression of genes through transcription activation. ... This leads to decreased levels of gene expression and is known as gene silencing.
What does histone acetylation do?
The role of histone acetylation.
Histone acetylation diminishes the electrostatic affinity between histone proteins and DNA, and thereby promotes a chromatin structure that is more permissive to gene transcription8,9,10,11.
Does acetylation increase charge?
Lysine acetylation can generate highly charged enzymes with increased resistance toward irreversible inactivation.
