The character, Sheldon Cooper, from The Big Bang Theory meets criteria in the DSM-IV for Asperger's Disorder.

What mental disorder does Sheldon have?

In the television show Big Bang Theory, Sheldon Cooper, a theoretical physicist who shows signs of Asperger Syndrome and Obsessive-Compulsive Personality Disorder, has a compulsive need to knock three times, say the persons name three times, and repeat for a total of three times.

Does Jim Parsons actually have Aspergers?

I asked the writers and they said no,” Parsons said. “He has Asperger traits. But their saying that took away a social responsibility.”