Donkeys can kill coyotes. They are often are used as guard animals to protect other livestock from predators, including coyotes.

Will donkeys fight off coyotes?

Generally, yes, a guard donkey will fight off a coyote.

They're not fighting out of some instinct to protect your sheep, but rather reacting against a strange animal encroaching on their territory. There's no difference, really, to the sheep around the donkey, because they get to stay safe and keep on grazing.

What animal kills coyote?

Cougars, wolves, grizzly bears and black bears are known to kill coyotes, according to the U.S. Department of Agriculture Forest Service. Golden eagles have been known to swoop down and take young coyotes. Humans kill coyotes too, for their fur and in attempts to control their populations.