Pleural effusion is an uncommon manifestation of amiodarone toxicity and is usually associated with amiodarone-induced interstitial pneumonitis.

What lung problems does amiodarone cause?

Several forms of pulmonary disease occur among patients treated with amiodarone, including interstitial pneumonitis, eosinophilic pneumonia, organizing pneumonia, acute respiratory distress syndrome (ARDS), diffuse alveolar hemorrhage (DAH), pulmonary nodules and solitary masses, and also (rarely) pleural effusion.

What causes sudden onset pleural effusion?

Congestive heart failure is the most common cause of transudative pleural effusions, while infection (pneumonia) and malignancy are the most common causes of exudative pleural effusions.