PPIs are most effective when the parietal cells are stimulated to secrete acid, as they are after a meal; as such, PPIs should be administered before a meal [9] . Acid inhibition by PPIs decreases gastric acid levels without the disruption of G-cells. ...

Why should PPIs be taken on an empty stomach?

PPIs include brand names such as Nexium and Prilosec. The medications, available both over the counter and by prescription, are most effective when taken on an empty stomach. PPIs circulate in the blood to block the stomach's acid pumps, which are activated when you eat.

Should PPIs be taken before meals?

For best results, take a PPI 30 minutes before you eat a heavy meal, or on an empty stomach at the time of the day when you've noticed you have the most discomfort.