Ketogenesis is strongly suppressed by insulin and is stimulated in states of insulin deficiency and glucagon excess ((4),(6)).

Does insulin cause Ketogenesis?

Ketogenesis can be upregulated by hormones such as glucagon, cortisol, thyroid hormones, and catecholamines by causing a more significant breakdown of free fatty acids, thus increasing the amount available to be used in the ketogenic pathway. However, insulin is the primary hormonal regulator of this process.

Do Ketones stimulate insulin?

Ketone bodies stimulate modest insulin release, and they also feedback negatively on hormone sensitive lipase (HSL) activity in adipocytes. Ketone bodies are preferred fuel in the brain during starvation.