P-glycoprotein, the most extensively studied ATP-binding cassette (ABC) transporter, functions as a biological barrier by extruding toxins and xenobiotics out of cells. In vitro and in vivo studies have demonstrated that P-glycoprotein plays a significant role in drug absorption and disposition.

What is the role of P-glycoprotein?

The general function of P-glycoprotein is now known to protect the body from harmful substances by: Removing drugs absorbed in the intestines back into the gut lumen. Maintaining the integrity of the blood brain barrier. Removing drugs from the kidneys and liver into the urine and bile respectively.

What is the mechanism of P-glycoprotein?

Human P-glycoprotein (ABCB1) is a primary multidrug transporter located in plasma membranes, that, utilizes the energy of ATP hydrolysis to pump toxic xenobiotics out of cells. P-glycoprotein employs a most unusual molecular mechanism to perform this drug transport function.