During the first few weeks of treatment, the skin lesions and surrounding areas will feel irritated and look red, swollen, and scaly. This is a sign that fluorouracil is working. Do not stop using fluorouracil unless your doctor has told you to do so.

How do you know when to stop using fluorouracil cream?

After continued application, the damaged skin becomes painful and inflamed with a beefy-red appearance with erosions and crusting. At this point, the medication should be stopped.

What happens if you stop using fluorouracil?

Fluorouracil may cause redness, soreness, scaling, and peeling of affected skin after 1 or 2 weeks of use. This effect may last for several weeks after you stop using the medicine and is to be expected.