Splitting unscored tablets is considered “off-label” because each split tablet dose may not have equal drug strength. However, splitting drugs with a long half-life and wide therapeutic index—such as those used to treat chronic asymptomatic conditions like hypertension or dyslipidemia—should pose minimal risk.

Can amiodarone be cut in half?

Take this medicine by mouth • Swallow the tablets whole. Do not crush or chew your tablets • If you feel the effect of your medicine is too weak or too strong, do not change the dose yourself, but ask your doctor. Amiodarone tablets should not be given to children and adolescents.

Can you cut simvastatin in half?

Cholesterol-Lowering Drugs That Can Be Cut in Half

Although they lack this groove, you may still be able to cut these medications in half. They include: Simvastatin (Zocor) Atorvastatin (Lipitor)