Urease is a metalloenzyme evenly distributed in the human body, including in the CNS, responsible for catalyzing the hydrolysis of urea into carbon dioxide and ammonia, the latter of which can be protonated to form ammonium, resulting in an increase in pH with consequences to pathogen-host interaction (Rutherford, 2014 ...

How does the enzyme urease work?

They are nickel-containing metalloenzymes of high molecular weight. These enzymes catalyze the hydrolysis of urea into carbon dioxide and ammonia: ... The carbamate spontaneously and rapidly hydrolyzes to ammonia and carbonic acid. Urease activity increases the pH of its environment as ammonia is produced, which is basic.

What is the mechanism of urease activity?

The hydrolytic enzyme urease is responsible for the catalytic decomposition of urea to volatile ammonia and carbon dioxide [1]. The enzyme releases ammonia and carbamate, which in turn spontaneously generate the products.