In extremely high doses, some alkaloids can make inflammation worse or be poisonous. Fortunately, that's not the case for the edible nightshades you're picking up in the produce aisle.

Are alkaloids bad for you?

Alkaloids can be dangerous in large doses. In fact, there are many other plants in the nightshade family that are poisonous to humans (like, ahem, tobacco). Even though they contain low levels of alkaloids, edible nightshades might, to some people, seem guilty by association.

Can you be allergic to alkaloids?

In some individuals, alkaloids may cause a severe and life-threatening allergic reaction known as anaphylaxis. A person should seek urgent medical attention if they experience or witness any of the following signs: swelling of the face, mouth or throat. coughing.