Working with demons, Nick contacted Lucifer in the Empty and learned of a way to resurrect him. Using Jack's blood, Nick succeeded in bringing Lucifer back from the Empty, but was foiled by Jack, who imprisoned Lucifer and killed Nick to stop him from trying again.

Who kills Lucifer in supernatural?

After stealing his son's power, Lucifer was fought for a final time by Dean powered by Michael who Dean was acting as a vessel to. With the help of Michael, Dean finally killed Lucifer with an archangel blade.

Does Sam become Lucifer?

Sam Winchester (Jared Padalecki)

Sam was always meant to be Lucifer's true vessel in his apocalyptic fight with Michael, but Sam steadfastly refused. After finally giving in, he was able to turn on Lucifer and force them both into the cage at the end of season 5.