Propofol provides at least as effective sedation as midazolam and results in a faster time to extubation, with an increased risk of hypotension and higher cost.

Can sedatives cause hypotension?

Respiratory depression is commonly seen and often enhanced by co-administration of additional sedative agents. Hypotension may result from decreased sympathetic tone or vasodilation from histamine release.

Why does sedation cause hypotension?

Hypotension encountered during sedation is usually attributed to either vasovagal episodes or the use of sedative and anesthetic agents that depress sympathetic outflow to the cardiovascular system.