Direct oral anticoagulants (DOACs), particularly direct factor Xa inhibitors, have been associated with prolongation of the prothrombin time and the international normalized ratio (INR). Although DOACs do not require monitoring, elevations in the INR have been reported in in vitro and observational studies.

Does rivaroxaban increase INR?

Purpose: Direct factor Xa inhibitors such as rivaroxaban or apixaban may prolong prothrombin time (PT) and elevate international normalized ratio (INR).

Does eliquis affect INR or PTT?

As a result of FXa inhibition, apixaban prolongs clotting tests such as prothrombin time (PT)/ INR, and activated partial thromboplastin time (aPTT).