Budesonide is a corticosteroid drug which is rapidly broken down by the liver, reducing corticosteroid-related side effects (e.g., moon face).

Does budesonide cause puffy face?

The most serious signs of this reaction are very fast or irregular breathing, gasping for breath, or fainting. Other signs may include changes in color of the skin of the face, very fast but irregular heartbeat or pulse, hive-like swellings on the skin, and puffiness or swellings of the eyelids or around the eyes.

Does budesonide make you gain weight?

Weight gain wasn't a side effect reported in clinical studies of budesonide ER oral tablets. But weight gain is a common side effect of corticosteroids. (Budesonide is a corticosteroid.) Keep in mind that budesonide can also cause swelling in your arms and legs.