While prednisone is not a stimulant, it can make you feel more alert or jittery. “It doesn't really interrupt sleep, but some patients find it keeps them awake when they don't want to be,” Dr. Ford says. What you can do: “If it's possible, we recommend you take your whole dose in the morning,” he recommends.

Why cant I sleep when I take prednisone?

— M.H.S. Dr. Roach: Prednisone is a powerful anti-inflammatory and immune-system suppressor that is used for many conditions. It can cause some degree of insomnia in 50 to 70 percent of those who take it, but the higher the dose, the more likely the insomnia.

Do prednisone pills keep you awake?

Take prednisolone once a day in the morning so it doesn't keep you awake. The most common side effects of prednisolone are insomnia, weight gain, indigestion and sweating a lot. Taking prednisolone can make you more likely to get infections.