Prednisone and other steroids can cause a spike in blood sugar levels by making the liver resistant to insulin. The pancreas produces insulin to control blood sugar levels. Diabetes can result from a fault in the way that the body reacts to insulin or a problem with the production of insulin in the pancreas.

Why do corticosteroids cause hyperglycemia?

Steroids stimulate glucose production by the liver and inhibit peripheral glucose uptake, resulting in insulin resistance. If the pancreas isn't able to make enough insulin to compensate, hyperglycemia can occur.

Does corticosteroids increase blood glucose?

One of the side effects of oral corticosteroids is that they can increase blood glucose levels and increase insulin resistance, which can lead to type 2 diabetes.