Mechanism of Action. Increased renin release from the juxtaglomerular cells is caused by several conditions: reduction in renal blood flow from heart failure, blood loss, hypotension or ischemia of the kidneys, sodium diuresis (excessive sodium loss in urine), and beta-adrenergic stimulation.
What stimulates the release of renin?
Renin is a proteolytic enzyme that is released into the circulation by the kidneys. Its release is stimulated by: sympathetic nerve activation (acting through β1-adrenoceptors) renal artery hypotension (caused by systemic hypotension or renal artery stenosis)
Is renin released when blood pressure is high?
As part of a homeostatic feedback circuit, blood pressure in turn affects the synthesis and release of renin from the juxtaglomerular cells of the kidney, with an increase of blood pressure inhibiting and a decline of blood pressure stimulating the renin system.
