On a cellular/molecular level, central sensitization may be reversed through degradative glutamate receptor pathways. This, however, rarely happens. Instead, cortical brain regions may serve in a top-down regulatory capacity for the maintenance or alleviation of pain.
Can central sensitization go away?
Treatments for central sensitization include pharmacological options, exercise therapy, and sleep management, as under the right conditions, central sensitization is manageable and often times reversible.
How do you calm central sensitization?
Often used drugs to treat central sensitization include:
- acetaminophen (paracetamol) - primarily acts centrally reinforcing descending inhibitory pathways. ...
- serotonin- and norepinephrine-reuptake inhibitors - activate noradrenergic descending pathways together with serotonergic pathways.
